reported AGR to be an independent factor for predicting overall survival in patient with lung cancer 11.ĬKD is a clinical condition characterized by the propensity of poor nutrition and high levels of inflammation. To date, interestingly, there is increasing evidence showing that albumin–globulin ratio (AGR) can predict the survival of patients in many types of malignancies 9, 10. High albumin level or low globulin level is associated with better survival in patients with breast cancer, ovarian cancer or colorectal cancer 6, 7, 8. On the other hand, high globulin could be the results of chronic inflammation and the responses to various proinflammatory cytokines 5. Hypoalbuminemia is not only an index of malnutrition but also reflects the status of chronic inflammation 4. ![]() Clinical management guided by this novel predictor could improve their long-term survival.Īlbumin and globulin, the two main constituents in the serum protein, have been reported to be implicated in the nutrition and systemic inflammation. Thus, it is urgent to identify promising prognostic markers which are clinically available, accurate and efficient for the purpose of risk stratification. However, these factors may be either inaccessible in clinical practice, costly or unstable to reproduce. Recently, several clinical and biochemical biomarkers, including serum level of gut microbiota-dependent trimethylamine N-oxide, aldosterone and urine neutrophil gelatinase-associated lipocalin concentration, have been identified as crucial prognostic factors for cardiovascular events or mortality in patients with CKD in previous reports 1, 2, 3. In conclusion, low AGR was independently associated with higher all-cause and CVD mortality risks in patients undergoing PD.Īlthough the treatment strategies to improve survival in chronic kidney disease (CKD) patients have been developed in the past few decades, the prognosis still remains poor. The predictive ability of AGR for mortality risk was superior to that of other biomarkers based on AUC calculations. ![]() The fully adjusted hazard ratios for the low AGR group versus high AGR group were 2.12 (95% CI 1.34–3.35, p = 0.001) and 2.58 (95% CI 1.42–4.7, p = 0.002) for all-cause and CVD mortality, respectively. Univariate Cox analysis showed that low AGR was significantly associated with worse outcomes in terms of all-cause and CVD mortality and it remained an independent predictor in the multivariate models. Among the study participants, there were 265 (47.83%) men and the mean follow-up time was 3.87 ± 3.15 years. The predictive value of AGR on mortality risk was compared with other markers using area under the receiver operating characteristic curve (AUC) analysis. ![]() Baseline patient’s socio-demographic data, pharmacotherapy, comorbidities, laboratory and PD-related parameters were collected and used in the multivariate Cox models. The outcomes of interest were all-cause mortality and cardiovascular disease (CVD) mortality. A total of 554 incident patients undergoing PD from January 2001 through July 2016 were enrolled for this retrospective observational study. However, no study was done to explore the value of AGR in peritoneal dialysis (PD) patients. There is increasing evidence showing that albumin–globulin ratio (AGR) can predict the survival of patients in many types of malignancies.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |